Objective  To investigate the fungal species distribution, liability factors, therapy and prevention of fungal septicemia.
Methods  A time-matched case-control study was conducted in 30 patients fromApril 2011 to November 2012 with fungal septicemia.
Results  Of the pathogens in 30 cases with fungal septicemia, 43.3% was Candida albicans, 23.3% was Candida tropicalis, and 10% was Candida parapsilosis. All 30 cases with fungal septicemia were hospital acquired. Malignant hematological system disease( 33.3% ) , COPD( 23.3% ) , and diabetes ( 20.0% ) were the main predisposing diseases. Broadspectrumantibiotic use( 86.7% ) , endovascular prosthesis( 60.0% ) , parenteral alimentation( 53.3% ) were the major risk factors. All 30 cases received systemic anti-fugal therapy. The efficacy rate of amphotericin B therapy was higher than that of fluconazol ( P =0.002) and voriconazole( P = 0.006) . 13 cases( 43.3% ) were cured or significantly improved, and 17 cases( 56.7% ) were dead.
Conclusions  The most frequently fungi was Candida albicans in fungal septicemia. Malignant hematological system disease and COPD were main predisposing diseases. Broad-spectrumantibiotic use and parenteral alimentation were independent risk factors. Anti-fugal therapy with amphotericin B can achieve better prognosis. Early diagnosis, controlling risk factors, and earlier empirical antifungal therapy are keys to reduce mortality of fungal septicemia.

Citation： QU Jingjing,HU Chengping,LUO Bailing. Clinical Analysis of 30 Patients with Fungal Septicemia. Chinese Journal of Respiratory and Critical Care Medicine, 2013, 12(4): 353-355. doi: 10 . 7507 /1671 -6205 . 20130085 Copy